Our research focuses on the processes of protein folding and misfolding and how these processes can lead to widespread aging-related diseases such as Alzheimerís and Parkinsonís disease. Self-assembly of proteins seems to be a generic process but results in insoluble fibrillar structures that can be toxic to the cell but can also have unique material properties. Our aim is to dissect and influence these self-assembly processes using biophysical tools such as single molecule fluorescence, atomic force microscopy and sub-diffraction microscopy, in order to develop new strategies to counteract protein misfolding diseases.

To contact us:

Jan Bieschke Ph.D.

1 Brookings Drive

Brauer 2033

St. Louis MO, 63108

Office Phone: 314-935-7038

Lab Phone: 314-935-3959

Fax: 314-935-7448

Email: bieschke[at]wustl.edu

Age-Related Protein Misfolding

Laboratory of Jan Bieschke, Ph.D.

Center for Biological and Systems Engineering

Text Box: Lab News

Heike Wobstís paper on the effect of the green tea polyphenol EGCG on tau aggregation has just come out in FEBS Letters. EGCG is surprisingly potent and inhibits tau aggregation at 1:100 ratios!  














Kathrin Andrich receives Travel award to the 59th Meeting of the Biophysical Society in Baltimore, Feb. 7-11, 2015.



Lab outing to the Saint Louis city museum. Sometimes it helps to be a small kid...

Age-Related Protein Misfolding

Laboratory of Jan Bieschke, Ph.D.

Center for Biological and Systems Engineering